Site-specific PEGylation of lidamycin and its antitumor activity
نویسندگان
چکیده
منابع مشابه
Site-specific PEGylation of lidamycin and its antitumor activity
In this study, N-terminal site-specific mono-PEGylation of the recombinant lidamycin apoprotein (rLDP) of lidamycin (LDM) was prepared using a polyethyleneglycol (PEG) derivative (M w 20 kDa) through a reactive terminal aldehyde group under weak acidic conditions (pH 5.5). The biochemical properties of mPEG-rLDP-AE, an enediyne-integrated conjugate, were analyzed by SDS-PAGE, RP-HPLC, SEC-HPLC ...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2015
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2015.03.006